Embark on an exciting cross-country road trip from Boston, Massachusetts to Santa Ana, California with our best of list. Discover stunning landscapes, iconic structures, and delicious cuisine.

Plan your trip from Boston to Santa Ana by considering different routes available, their costs, distance, and time with current gas prices. Get our recommendation for the best route.

Planning a road trip from Boston to Santa Ana? Discover the fastest and slowest routes, distance, driving time, and traffic patterns to make the most of your cross-country trip.