Roadtripping from Cape Girardeau to Columbus: The Best Routes and Stops to Make

If you're planning a road trip from Cape Girardeau to Columbus, you're in for a treat. With a variety of routes and stops to choose from, there's no shortage of things to see and do along the way. Here are some of the best options to consider for your journey.

The routes

Option 1: I-70 E

The most direct route from Cape Girardeau to Columbus is via I-70 E, which covers a distance of 486 miles. This route passes through major cities like St. Louis and Indianapolis and takes approximately 7 hours and 45 minutes to drive non-stop. Of course, with stops along the way, you can easily turn this into a multi-day adventure.

Option 2: I-64 E and I-71 N

Another option is to take I-64 E to Louisville, then switch to I-71 N to Cincinnati and finally take I-71 N to Columbus. The total distance covered on this route is 515 miles, and the drive should take around 8 hours and 30 minutes. This route takes you through the beautiful Blue Ridge Mountains and offers a chance to stop in both Louisville and Cincinnati.

Option 3: Scenic Route

For those who would rather take their time and enjoy the scenic route, you can take highways like U.S. 50 and U.S. 52 to make your way to Columbus. Though this is not the most direct route, it offers stunning views of the countryside, rolling hills, and the Ohio River. Depending on how many stops you make along the way, this route could take anywhere from 10 to 12 hours.

Recommended Stops

St. Louis, Missouri

If you're taking the I-70 route, St. Louis is a great place to stop and stretch your legs. The Gateway Arch is a must-see attraction, and the city's brewery scene is top-notch.

Louisville, Kentucky

If you're taking the I-64 and I-71 route, consider spending a night in Louisville. Home to the world-famous Kentucky Derby, there's plenty to see and do in this city. Visit the Louisville Slugger Museum & Factory or take a stroll through Waterfront Park.

Cincinnati, Ohio

When passing through Cincinnati, stop and visit the Cincinnati Zoo & Botanical Garden, the National Underground Railroad Freedom Center, or take a walk through the historic Over-the-Rhine neighborhood.

Hocking Hills State Park, Ohio

If you're taking the scenic route, a stop at Hocking Hills State Park is a must-see. This park boasts waterfalls, caves, hiking trails, and mesmerizing views of the surrounding rolling hills.

No matter which route you choose, there are plenty of places to explore on your journey from Cape Girardeau to Columbus. Enjoy the ride, take your time, and make lasting memories along the way.