Points of Interest between Creve Coeur, Missouri to Biloxi, Mississippi

picture of Creve Coeur, Missouri

Exploring the Best of the Midwest and the Gulf Coast

If you're traveling between Creve Coeur, Missouri and Biloxi, Mississippi, you're in for a road trip filled with diverse landscapes, rich history, and plenty of natural beauty. One of the must-see stops along the way is Como, MS, the halfway point that offers a charming mix of small-town charm and Southern hospitality.

1. Wister Gardens - Nestled on the campus of Delta State University in Cleveland, MS, Wister Gardens is a picturesque spot that offers a serene escape from the hustle and bustle of the road. Visitors can stroll through beautifully landscaped gardens, featuring a stunning array of native plants, flowers, and towering trees. The tranquil ponds and flowing fountains add to the peaceful ambiance, making it a perfect place to relax and soak up the natural beauty.

2. Tunica RiverPark & Museum - As you make your way through the Mississippi Delta, a stop at the Tunica RiverPark & Museum is a must for history enthusiasts and nature lovers alike. Perched on the banks of the mighty Mississippi River, this unique attraction offers panoramic views of the river and its surrounding wetlands. The museum showcases the rich cultural and natural history of the region, while the RiverPark features walking trails, observation decks, and a boardwalk that allows visitors to experience the diverse ecosystem up close.

3. Vicksburg National Military Park - History buffs won't want to miss the chance to explore the hallowed grounds of Vicksburg National Military Park. This historic site commemorates the pivotal Civil War battle that took place in Vicksburg, Mississippi, and is home to over 1,300 monuments and markers, as well as the restored U.S.S. Cairo gunboat. Visitors can take a self-guided driving tour or join a ranger-led program to learn about the significance of the battle and the soldiers who fought there.

4. Gulf Islands National Seashore - As you approach Biloxi, be sure to take a detour to the Gulf Islands National Seashore, where pristine white sand beaches and crystal-clear waters await. This protected area encompasses a series of barrier islands along the Gulf Coast, offering opportunities for swimming, shelling, birdwatching, and picnicking. Whether you're looking to relax on the beach or explore the coastal wilderness, Gulf Islands National Seashore is a breathtaking natural oasis that's worth the visit.

5. Jefferson Davis Presidential Library - Once you reach the historic city of Biloxi, make time to visit the Jefferson Davis Presidential Library, which is located on the beautiful grounds of Beauvoir. This historic site was the last home of Jefferson Davis, the President of the Confederate States of America, and now serves as a museum and library dedicated to preserving his legacy. Visitors can tour the antebellum mansion, stroll through the landscaped gardens, and explore exhibits that offer insight into the life and times of this influential figure in American history.

The best route to experience the top attractions between Creve Coeur, Missouri and Biloxi, Mississippi is to take I-55 S and I-69 S before stopping in Como, MS for a restful break and exploring the local sights. From Como, continue on I-55 S and I-20 E to reach the Mississippi Delta, then follow the scenic route along the Gulf Coast to Biloxi. This road trip offers a perfect blend of cultural heritage, natural beauty, and historic landmarks that capture the essence of the Midwest and the Gulf Coast.